News Items

10 Mar 2009 |
Obama Lifts Bush's Strict Limits on Stem Cell Research

On Monday, President Barack Obama  lifted a nearly 8-year ban on the use of federal funds for embryonic stem cell research. The ban was enacted by former president George W. Bush, limiting researchers to a small number of stem cell lines created prior to August, 2001.

The lifting of federal restrictions on stem cell research is being heralded in the scientific community.  Federal funds from agencies like the National Institutes of Health are one of the primary engines of basic research leading to medical and healthcare breakthroughs. Most experts expect the pace of stem cell research to increase significantly, though the promise of treatments or cures is still years away. The first human trial of a spinal cord injury therapy derived from embryonic stem cells was just approved by the FDA in January.

Not only will there be new funding available for stem cell research, but those researchers who relied on state or private dollars to fund their stem cell research programs during the ban will no longer have to run duplicate labs or facilities to separate their privately-funded research from that which was federally funded.

Original Article
08 Mar 2009 |
Spacecraft Seeks Earth-Like Planets

Is there life on other planets? NASA's newest mission hopes to shed light on this question. Last Friday, NASA launched the Kepler Mission, a spacecraft-based telescope that will enable scientists to search a small area of the Milky Way for earth-like planets, capable of supporting life.

At the heart of the mission is the Kepler telescope. The telescope contains a very sensitive photometer, capable of measuring very small changes in light intensity. By continuously monitoring the light being emitted by over 100,000 stars, it can detect a subtle "dimming" of a given star's light if an orbiting planet passes in front (view a graphic of the "transit method" for detecting planets).

The mission's goal is to identify planets in the "habitable zone," the distance from a star where a planet is likely to have liquid water present. Once a planet is detected, NASA researchers will use information including the planet's period (the time it takes to orbit the star), the star's temperature and mass, and the planet's mass to calculate the planet's surface temperature.

For the next several months, Kepler will travel to its final vantage point: a carefully-calculated, unobstructed orbit around the sun. From there, Kepler's three-and-a-half year unblinking gaze will begin.

Original Article
Physics-Astronomy
16 Feb 2009 |
F.D.A. Approves Drug From Gene-Altered Goats

The Food and Drug Administration recently approved the first drug to be biologically produced from genetically modified livestock. The drug antithrombin, a protein which helps prevent blood clotting, will be produced by goats that have been genetically modified with the human version of the gene.

Cleverly, researchers spliced the gene in a specific part of the goat genome so that the goats would only produce the protein in their milk. It's relatively straightforward to isolate the protein drug from other milk proteins and package it for market.

Given that the "bio-pharming" approach has been discussed for decades, it will be interesting to see if the promises of cheaper and higher quality drugs come true.

However, some animal rights groups have expressed concern about the use of animals for drug production. Other groups are concerned about monitoring these transgenic animals, so that they do not enter the food supply.

Original Article
16 Feb 2009 |
Birth of Octuplets Puts Focus on Fertility Clinics

The birth of octuplets to a California woman who already had six children, all fourteen via IVF, has drawn strong criticism from both the medical and ethics communities. In the United States, the $1 billion assisted reproductive technology industry results in more than 50,000 babies per year. A third of these are "multiple births," twins or higher. These children are at elevated risk for a variety of health problems.

The article highlights the tension between patients, physicians, and insurance companies. Patients naturally want a child, physicians want to maximize their success rates but minimize the possibility of multiple births, and insurance companies often won't pay for the procedure. With the cost of IVF at $10,000 per attempt, doctors are under pressure from patients to implant multiple embryos at once.

Though voluntary professional guidelines recommend implanting only two embryos per attempt, this was obviously not followed in the California octuplets case. Some have also argued that the physician should have declined to treat a single woman who already had six children.

Original Article
Medicine-Health
26 Jan 2009 |
Drug Making's Move Abroad Stirs Concerns

You'd probably be concerned if you knew that the US was at the mercy of countries like China and India for many of your prescription medications. Yet, this is exactly the situation for many key drugs you might take for an infection, diabetes, or even high blood pressure. More than 85% of pharma plants producing off-patent medications are found overseas.

With China's melamine scandal fresh on everyone's minds (this toxic chemical was found in infant formula), drug safety is a primary concern. It's also scary to think that the US could be cut off from potentially lifesaving drugs, should a foreign country decide to scale back trade relations with us. The time necessary to build a new antibiotic plant on US soil? Two years.

Original Article
Medicine-Health
26 Jan 2009 |
Study Finds New Evidence of Warming in Antarctica

New research from the University of Washington and NASA indicates that climate change in Antarctica is more widespread than previously thought. Using satellite and weather station data from 1957-2006, researchers deduced that both the western and eastern halves have warmed significantly, approximately 0.1 degree Celsius overall per decade. The warming has serious repercussions for melting ice, sea levels, and wildlife.

Previously, global warming skeptics pointed to earlier data from scattered ground-based coastal sensors that suggested the eastern region of Antarctica was actually cooling, an observation at odds with climate change predictions. The current study, however, with its broader geographic coverage of the continent, suggests that all of Antarctica is warming.

Original Article
26 Jan 2009 |
My Genome, My Self

The New York Times recently featured a comprehensive and well-written article by noted Harvard psychologist Steven Pinker on the rise of consumer genomics. Pinker is a participant in the Personal Genome Project, an ambitious initiative to sequence the DNA of 100,000 volunteers for the purpose of better understanding how genes, health, and behavior are interrelated.

He also submitted a spit sample to 23andMe, a direct-to-consumer genetic testing company that promises information about not only disease risk, but also personal traits like food preference, athletic ability, and baldness. In Pinker's case, the genetic test results were, well, flat-out wrong. Despite genetic predictions to the contrary, he likes coffee and beer, prefers hiking and cycling to squash, and has a full head of hair.

The article reinforces several important messages about our current understanding of the relationship between genes and health, personality, intelligence, and other complex traits. Most genetic tests provide only limited information about your odds of developing an illness, being bald, or preferring brussel sprouts over broccoli.  Both genes and our environment play a key role in shaping who we are. For a given illness or trait, there are likely hundreds, if not thousands of genes that, along with environment, make us who we are. Current research tools are not yet sophisticated enough to tease out many these relationships.

We will, no doubt, understand more about our genetic selves in the years to come; research initiatives like the Personal Genome Project and Northwestern's NUgene project will hopefully shed new light on many genetic mysteries.  For the time being, as Pinker points out, if you want to know if you're good at math, take a math test.  And the simplest genetic test is your family history.

Original Article
20 Jan 2009 |
Mars Vents Methane in What Could Be Sign of Life

Using special infrared telescopes, NASA scientists have discovered the presence of regular methane “plumes” on Mars, further raising the possibility that life once existed – or currently exists – on Mars. Methane gas is one of the simplest organic molecules, a common byproduct of biological life. In fact, more than 90% of the Earth’s methane comes from biologic sources.

It is important to point out that the presence of methane is, in and of itself, not conclusive evidence of life. Methane can be produced from purely non-biological chemical reactions. Based on NASA’s current findings, it’s impossible to say if the gas is from biologic or geologic sources.

Interestingly, the article also highlights recent research showing that microbial life can live quite happily miles underground. A team from Indiana University recently discovered microbes living two miles beneath the Earth’s surface. These microbes harnessed energy from the radioactive decay of nearby rocks to generate fuel. If Martian life does actually exist, it would likely be deep underground, where the temperature is significantly warmer and liquid water would flow freely.

It will be interesting to see if the next Mars rover mission, scheduled for 2011, will target one of the suspicious methane-rich sites.

Original Article
Physics-Astronomy
11 Jan 2009 |
Research on Embryonic Stem Cells at a Crossroads

Geron, a California-based biotech company, plans to begin human testing soon for the first-ever embryonic stem cell therapy. The company has been working for the last ten years to develop a treatment for spinal cord injury, submitting a 22,500-page application last year to the Food and Drug Administration. Approval of this application is the final step before clinical trials can begin.

Clinical trials generally occur in three phases (I, II, and III) and are designed to carefully evaluate safety, dose, how well the drug works, and how well it compares to current therapies. The entire process can take more than a decade (and tens of millions of dollars) to complete. The National Institutes of Health has a website that explains the process in detail, including a list of active clinical trials.

As the Chicago Tribune article points out, much is at stake. Should the trial prove effective, the road will be paved for future studies. But if the new therapy is not effective, there is a fear that the public and policy makers may lose enthusiasm. Many researchers caution that high expectations need to be kept in check. California stem cell researcher Evan Snyder said, "If you had even bought Christopher Reeve an extra segment of spinal function he would [have been] off his ventilator. He would not be running a marathon, but you've changed his life."

The article also discusses the negative impact of President Bush's restrictive policies on federal funding for embryonic stem cell research. Present-elect Barack Obama has said he will lift federal funding restrictions as one of his first acts in office.

[UPDATE - 1/23/09: The FDA has approved Geron's request to begin clinical trials]

Original Article
21 Dec 2008 |
Vatican Ethics Guide Stirs Controversy

Last week the Catholic Church's solidified its official position against the use of assisted reproductive technologies with the release of a new position paper, Dignitas Personae -– Latin for "the dignity of a person." It had been more than two decades since the Vatican had weighed in on issues like in vitro fertilization, embryo freezing, and embryo genetic testing. These technologies have grown significantly in use over the last 20 years.

The Church condemned technologies in which embryos may be lost, including in vitro fertilization and embryonic stem cell research. However, it is well-known that many Catholic families use in vitro fertilization to overcome issues of infertility, and not all Catholic clergy agree that in vitro fertilization is morally unacceptable.

Somewhat surprisingly, the document does not universally condemn genetic therapies designed to alleviate suffering or cure disease – even if these therapies might be passed down from generation to generation.  The document states, "Because the risks connected to any genetic manipulation are considerable and as yet not fully controllable, in the present state of research [emphasis added], it is not morally permissible to act in a way that may cause possible harm to the resulting progeny.

Dignitas Personae is available online at the Vatican's website.

Original Article
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