News Items

19 Dec 2008 |
FDA Verdict Could Determine Future Of Personalized Medicine

Pharmaceutical giants Amgen, Bristol-Myers Squibb, and Eli Lilly have asked the Food and Drug Administration (FDA) to require that patients take a genetic test before receiving their anti-cancer drugs.

The move is designed to identify those patients whose cancers are most likely to respond to a particular drug, speeding the course of treatment and reducing potentially harmful side effects. Recent genetic studies have shown that certain classes of drugs are completely ineffective in patients whose cancers are of a particular genetic subtype. It's also well-known that individuals metabolize drugs differently, based on their genetic makeup.

For example, in 2007 the FDA approved a genetic test for patients taking warfarin, an anti-clotting drug. Dangerous side effects can occur in patients whose genes limit their ability to metabolize the drug. The FDA also recently approved a genetic test to determine which patients are good candidates for the anti-breast cancer drug Herceptin.

For more on this topic, see Dr. Rex Chisholm's feature article on personalized medicine.

Original Article
05 Dec 2008 |
Stem Cell Efforts Hit State Roadblock

In 2004, California voters passed Proposition 71, which provided $3 billion in taxpayer-funded research support for stem cell research. The money is to be spent at a rate of $300 million per year for 10 years.

According to San Diego Union-Tribune, $614 million has been distributed in the form of research grants thus far, but none of these grants have been for projects whose goal is to create stem cells through a process known as therapeutic cloning. The problem has not been ethical opposition, or a lack of research groups requesting funds for therapeutic cloning. Rather, the research has been stopped by a shortage of women willing to donate their eggs.

Therapeutic cloning is a technique used to produce embryonic stem cells that are genetically matched to a particular recipient. Genetically matching "donor" stem cells with their recipient is important to prevent rejection by the recipient's immune system, in the same way that organ transplants must be carefully matched.

The technique starts with an unfertilized egg donated from a woman. The genetic material of the donor egg cell is removed and replaced with the genetic material of the recipient. The egg then chemically activated, making it divide to an early embryonic stage. Stem cells can then be collected that are a perfect immunological match for the recipient. The technique has been accomplished in monkeys, but never in humans (a South Korean research team's claim to have done this in 2004 was subsequently proved fraudulent). Another description of therapeutic cloning can be found at the University of Utah's genetics site.

Unfortunately, donating eggs is a somewhat lengthy and risky process, which includes taking fertility drugs and being subjected to medical procedures. Individuals who donate eggs to fertility clinics for reproductive purposes (e.g. making a baby) are usually compensated at a rate of $3,000-5,000. However, in California, egg donors for stem cell research are banned from accepting compensation, aside from reimbursement for time away from work and transportation costs. The reason for the ban is so that money will not be a factor in a person's decision to donate. Not surprisingly, there are few donors.

However, researchers have argued strongly in favor of compensating donors, leveling the field for women who donate for research versus reproductive purposes. In fact, women in the UK undergoing infertility treatments have been "encouraged" to donate eggs in exchange for discounted medical services. This approach has apparently yielded some success.

A 2007 New York Times article further explores the pros and cons of paying women for eggs.

Original Article
05 Dec 2008 |
CNN Drops Science-Tech Unit and Veteran Reporter

The Atlanta Journal-Constitution reports that CNN's seven-person science and technology reporting group, led by anchor Miles O'Brien, has been shut down. The move is reportedly editorial, not economic. A CNN spokesperson says that science and technology reporting will be now be moved into Anderson Cooper 360's "Planet in Peril" series.

Why CNN would chose to do this isn't exactly clear. Many of the most pressing issues affecting our country have deep science and technology roots: energy, health care, climate change, and even national security. In fact, a report released this week by a US government bipartisan commission noted that the US is likely to be targeted with a biological weapons attack in the next five years. With seven fewer reporters on the job, in-depth coverage of these important issues will be scant.

Perhaps the first story for "Planet in Peril" could be the growing media disinterest in covering science. The topic would be especially appropriate for a planet in peril.

Original Article
05 Dec 2008 |
Magic and the Brain: How Magicians “Trick” the Mind

This Scientific American article explores how magicians use the brain’s wiring to produce illusions.

For example, “change blindness” is the tendency of a viewer not to notice significant visual changes in a particular scene if they are masked by a temporary flicker, rapid movement, or other interruption (for a dramatic demonstration, watch this video). Because the pre- and post-change environments cannot be compared side by side, the changes are missed.

The article gives other neat examples, too, like the tendency of our visual system to follow movement, which can be covertly manipulated by the magician with head or hand movements.  Straight or curved hand motions affect our visual system in different ways, producing different levels of attention on the gesture.

Original Article
The Brain
01 Dec 2008 |
5 Myths About Our Ailing Health-Care System

Shannon Brownlee and Ezekiel Emanuel, two scholars from the National Insitutes of Health, tackle five common health care myths in this Washington Post article:

1. America has the best health-care in the world
2. Someone else is paying for your health insurance
3. We would save a lot if we could cut the administrative waste of private insurance
4. Health-care reform is going to cost a bundle
5. Americans aren't ready for a major overhaul of the health-care system

Clearly, the issue of health-care has struck a nerve with Washington Post readers.  In the last week, it has received 175 comments.

Original Article
Medicine-Health
24 Nov 2008 |
Name NASA's Next Mars Rover

How'd you like to go to Mars? Well, if you're in grade K-12, you have the opportunity to pick the name for NASA's next Mars rover. The winner will visit NASA's Jet Propulsion Laboratory in California for a tour and a chance to "sign" the rover headed to Mars.

NASA's Mars exploration website is here, including videos from the recent Phoenix lander mission and a history of all Mars missions.

Original Article
Physics-Astronomy
24 Nov 2008 |
Scientists Map Woolly Mammoth's DNA, Bringing 'Jurassic Park' Step Closer to Reality

Using hair from a 20,000 year-old mammoth, Penn State researchers have successfully deciphered more than half of the extinct mammal's DNA. The feat was made possible by new "high throughput" DNA sequencing technology, which is able to generate massive amounts of DNA sequence in very short order.

Not surprisingly, the mammoth's DNA is amazingly similar to the current-day African elephant. In fact, the close evolutionary relationship (~99.6% DNA identity) has led some to speculate that it might be possible to "fill in the gaps" of the missing mammoth DNA with elephant DNA. Then you'd be on your way to re-creating a complete set of genetic instructions for a mammoth. Get the genes into an egg, figure out how to trick the egg into thinking it's been fertilized, and...

Well, not so fast. As pointed out in the journal Nature, the idea of bringing a mammoth's DNA sequence "to life" faces enormous technical hurdles. Not least among these is that we do not yet have the technology to synthesize and assemble mammalian chromosome-length stretches of DNA (tens to hundreds of millions of letters). Currently, the record for a synthetic chromosome is approximately half a million letters. There's also the issue of getting the DNA appropriately packaged into chromosomes, getting the chromosomes, undamaged, inside an egg cell nucleus, figuring out how to activate the egg cell nucleus, etc. Let's just say that the mammoth won't be brought back from extinction any time soon.

But do stay tuned for news regarding the world's first synthetic bacterium. The J. Craig Venter Institute announced last summer that they had synthesized the Mycoplasma genitalium genome and were working on getting the synthetic genome working inside of a bacterial cell.

Here's a link to Penn State's Woolly Mammoth Genome Project site.

Original Article
16 Nov 2008 |
Scientists Take First Photos of Planets Orbiting Other Stars

Two groups of astronomers reported this week that, for the first time, they had directly laid eyes on planets outside our solar system. The two groups reported a total of four new "exoplanets:" three are orbiting a star 128 light years away, and another orbits a star 25 light years away. Given that 1 light year is approximately 5.9 trillion miles, these planets won't be visited any time soon.

Planets orbiting distant stars are difficult to see because the parent star's bright light overwhelms any reflected light that the planet may direct towards earth.  Although more than 300 exoplanets have been identified, their existence to date has been inferred by indirect means - for example, by observing a planet's effect on other celestial objects (stars, dust rings), or their ability to block light as they pass in front of a star.

Being able to directly image other planets will allow astronomers to determine their chemical composition and perhaps infer whether they could support life. For the current discovery, none of the four are believed to have life-friendly conditions.

A photo of the three-planet system can be found at the Lawrence Livermore National Laboratory website.

Original Article
Physics-Astronomy
16 Nov 2008 |
That Burger You're Eating Is Mostly Corn

In a strange twist on the "veggie burger" concept, University of Hawaii researchers have concluded that more than 90% of a typical fast food hamburger originally comes from corn. Not corn ground up and pressed into a patty, but corn eaten by cattle and metabolized to muscle, then eventually processed to hamburger. 

Of concern is that this work highlights the degree to which the American cattle industry depends on corn as feed. Corn is widely viewed as an environmentally "costly" crop, requiring lots of fertilizer, soil-damaging cultivation, and gas-burning heavy machinery. Grass-fed beef is viewed as not only friendlier to the environment, but also healthier. The tradeoff is that grass-fed cattle require much more land for grazing and grow more slowly. For a $0.99 hamburger, grass-fed beef just isn't a reality.

Original Article
12 Nov 2008 |
Scientists Decode Set of Cancer Genes

In an effort to better understand the genetics of cancer, researchers at the Washington University School of Medicine in St. Louis have completely sequenced the genome of a woman fatally afflicted with leukemia, a cancer of the blood. This was an important step because the exact genetic errors that lead to many cancers are not known.

To determine which genes might be involved in this particular form of leukemia, researchers performed a conceptually simple – but technically very challenging – experiment: compare the DNA sequence from the woman's leukemic bone marrow cells to DNA sequence from her own normal skin cells, and look for differences. Ideally, both cell types should have basically identical DNA sequences (all cells contain the same master set of DNA "instructions"). Differences arise, though, because cells acquire DNA mutations (errors) during one's lifetime. Some of these may contribute to disease.

After reading the 3 billion letters of her tumor and skin genomes many times over (~140 billion total letters of DNA sequenced!), they found 10 gene mutations in her marrow cells that likely led to the disease. Eight of these genes had not previously been linked to leukemia.

Exactly how these genes might contribute to leukemia remains to be determined. But researchers now have a new set of targets that may help in the search for better diagnostics and ultimately cures. Sequencing many more genomes of patients with leukemia will be necessary for the full genetic picture to emerge, but this is certainly a great start.

All of this work has been made possible by the completion of the Human Genome Project in 2003, and by amazing technical advances in our ability to sequence DNA.

More about the idea of “personalized medicine” – using genetic information to help determine the best course of health care – can be found in Dr. Rex Chisholm’s recent SiS article. You can also listen to an audio interview with Dr. Timothy Ley, who led the study, courtesy of NPR's Science Friday.

Original Article
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