Graduate Student, Laboratory of Thomas Hope
A cure for HIV may be lurking in unlikely hosts – monkeys. TRIM5α, a naturally occurring protein found in rhesus monkeys, blocks HIV from successfully infecting cells. Danielson and her colleagues have found that TRIM5α utilizes a cellular structure called the proteasome to destroy anything that has been marked with the protein ubiquitin. Understanding the way TRIM5α works with other cellular systems to defend against HIV infection could pave the way for designing better therapeutic interventions. In this image of a cell, the nuclei are yellow, the TRIM5α is orange, and chains of ubiquitin are pink.